Splash Biography
HOLLY STEACH, PhD student and long-time antibody entheusiast
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Major: Immunobiology College/Employer: Yale Year of Graduation: G |
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Brief Biographical Sketch:
Research Interests: I'm primarily interested in how your body recognizes pathogens or immune insults and generates lasting antibody-mediated protection. I have worked on antibody responses to HIV vaccine candidates, malaria, allergic asthma, influenza vaccination and infection, and now COVID mRNA vaccines. My current focus is on how cell metabolism impacts antibody responses, and how pharmaceutical drugs that alter cell metabolism can affect vaccine efficacy. Education/Employment History: B.S. Molecular, Cellular, Developmental Biology, University of Washington, Seattle, WA Former Research Technician in the laboratory of Dr. Marion Pepper, University of Washington, Seattle, WA (publication history https://orcid.org/0000-0003-0018-3129) Previous Splash Classes: -Why don't we have an HIV vaccine? (Fall 2016) Past Classes(Clicking a class title will bring you to the course's section of the corresponding course catalog)S4372: COVID Vaccines: from Cellular Immune Responses to Herd Immunity in Splash Spring 2021 (Apr. 24, 2021)
We will dive into what happens when you first get a vaccine for the novel SARS-COV2 Coronavirus. We will address questions like: What is an antigen? How does your body recognize that it is something to generate an immune response to, and how does that immune response protect you in the long-term? Why do we get side effects, and how does immunity from a vaccine compare to immunity after infection? We will also discuss how these processes within our bodies generate immunity at the population level, and how vaccination allows us to protect ourselves as a community.
S3167: Why don't we have an HIV vaccine? in Splash Spring 18 (Apr. 07, 2018)
If you can get a flu vaccine that will keep you from getting sick, how come you can't get an HIV vaccine?
Since the outbreak of the HIV/AIDS epidemic in the early 1980’s researchers have faced a variety of unique challenges in the search for a vaccine or a cure. Huge strides have been made in treatments, but we still have not found a vaccine that can prevent transmission of HIV.
Come learn what normally makes a good vaccine, why HIV is particularly difficult to combat with traditional vaccine strategies, and what creative ways researchers are coming up with to fight back against HIV!
S2689: How does your body know it's sick? in Splash Spring 17 (Apr. 08, 2017)
What happens inside your body when you get sick? When you encounter microbes, your immune system recognize invaders and becomes activated in order to fight the infection. Your immune system also has ways of remembering these microbes, so that next time you don't get sick. Come learn about your immune system, how it fights infections, and how vaccines can mimic these processes to help you remember microbes you've never seen!
S2305: Why don't we have an HIV vaccine? in Splash Fall 16 (Nov. 05, 2016)
If you can get a flu vaccine that will keep you from getting sick, how come you can't get an HIV vaccine?
Since the outbreak of the HIV/AIDS epidemic in the early 1980’s researchers have faced a variety of unique challenges in the search for a vaccine or a cure. Huge strides have been made in treatments, but we still have not found a vaccine that can prevent transmission of HIV.
Come learn what normally makes a good vaccine, why HIV is particularly difficult to combat with traditional vaccine strategies, and what creative ways researchers are coming up with to fight back against HIV!
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